Document Detail

History of fetal loss and other adverse pregnancy outcomes in relation to subsequent risk of preterm delivery.
MedLine Citation:
PMID:  12710800     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the association between maternal reproductive history and preterm delivery. METHODS: The 312 preterm delivery cases, studied in aggregate, and in subgroups (spontaneous preterm labor, preterm premature rupture of membranes, medically induced preterm delivery, moderate preterm delivery [gestational age at delivery 34-36 weeks], and very preterm delivery [gestational age at delivery <34 weeks]), were compared with 424 randomly selected women who delivered at term. Maternal medical records provided information on maternal reproductive history, pregnancy outcome, as well as sociodemographic characteristics. Using multivariate logistic regression, we derived maximum likelihood estimates of adjusted odds ratios (OR) and 95% confidence intervals (CI). RESULTS: A history of 2+ miscarriages was (OR = 2.2; 95% CI 1.2-3.9), but a history of 2+ prior induced abortions (OR = 1.2; 95% CI 0.7-2.0) was not, associated with preterm delivery in the index pregnancy. Analyses of preterm delivery subgroups indicated that a history of 2+ miscarriages was associated with an increased risk of spontaneous preterm labor (OR = 2.6; 95% CI 1.2-2.8), preterm premature rupture of membrane (OR = 1.8; 95% 0.7-4.4), and medically induced preterm delivery (OR = 1.9; 95% CI 0.8-4.2), though only the former approached statistical significance. Excess risk of preterm delivery was associated with maternal prior history of delivering a stillborn infant (OR = 10.7), a prior history of delivering a newborn that later died during the neonatal period (OR = 3.2), and a prior history of having a pregnancy complicated by spontaneous preterm delivery (OR = 6.0). Generally these associations were evident for each subgroup of preterm delivery, though inferences were often hindered by our relatively small sample size. CONCLUSIONS: These results support the hypothesis that maternal adverse reproductive history is associated with an increased risk of preterm labor and delivery.
Amira Y El-Bastawissi; Tanya K Sorensen; Clarisse K Akafomo; Ihunnaya O Frederick; Rong Xiao; Michelle A Williams
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Maternal and child health journal     Volume:  7     ISSN:  1092-7875     ISO Abbreviation:  Matern Child Health J     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9715672     Medline TA:  Matern Child Health J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA.
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MeSH Terms
Abortion, Induced / statistics & numerical data*
Abortion, Spontaneous / epidemiology*
Cohort Studies
Fetal Death / epidemiology*
Infant Mortality
Infant, Newborn
Obstetric Labor, Premature / epidemiology*,  physiopathology
Odds Ratio
Pregnancy Complications / epidemiology
Reproductive History*
Risk Assessment
Risk Factors
Socioeconomic Factors
Washington / epidemiology
Grant Support
R40MC00113//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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