Document Detail

History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study.
MedLine Citation:
PMID:  20228997     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners. METHODS: The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02-3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years. CONCLUSION: This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.
Qiang Li; Shinichi Kuriyama; Masako Kakizaki; Hong Yan; Toshimasa Sone; Masato Nagai; Yumi Sugawara; Kaori Ohmori-Matsuda; Atsushi Hozawa; Yoshikazu Nishino; Ichiro Tsuji
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-13
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  21     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1025-32     Citation Subset:  IM    
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
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MeSH Terms
Cohort Studies
Diabetes Mellitus / epidemiology*
Follow-Up Studies
Japan / epidemiology
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prostatic Neoplasms / epidemiology*
Regression Analysis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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