Document Detail

History and challenges surrounding ovarian stimulation in the treatment of infertility.
MedLine Citation:
PMID:  22463773     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the history of superovulation for ovulation induction, its contributions to reproductive medicine, and its impact on multiple births.
DESIGN: A search of the relevant literature using PubMed and other online tools.
RESULT(S): Infertility has been a condition known and studied for thousands of years. However, it was not until this past century that effective treatments were developed. With the advancement of our knowledge of the hypothalamic-pituitary axis, therapies utilizing gonadotropins were developed to stimulate ovulation. Not only could we now treat anovulatory infertility but also induce superovulation for IVF. With these successes came consequences, including increased multiple pregnancies. Several countries recognized the high costs associated with multiple births and implemented regulations on the infertility industry. The rate of triplet and higher-order multiples has declined over the past decade. This is largely attributed to a decreased number of embryos transferred. Nonetheless, the twin rate has remained consistently high.
CONCLUSION(S): Superovulation has become a routine medical therapy used for ovulation induction and IVF. With the development of this technology have come effective therapies for infertility and new ethical and medical challenges. Since the advent of gonadotropin therapy we have already developed technologies to improve monitoring and decrease hyperstimulation and high-order multiple pregnancies. In the future we anticipate new tools devised to optimize one embryo for one singleton live birth.
Stephanie A Beall; Alan DeCherney
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Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  Fertility and sterility     Volume:  97     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-30     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  795-801     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
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MeSH Terms
Embryo Transfer
Fertility Agents, Female / adverse effects,  history,  therapeutic use*
Fertilization in Vitro
Gonadotropins / adverse effects,  history,  therapeutic use*
History, 16th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, 21st Century
Infertility / history,  physiopathology,  therapy*
Multiple Birth Offspring
Ovulation Induction* / adverse effects,  history
Pregnancy, Multiple*
Risk Assessment
Risk Factors
Treatment Outcome
Grant Support
Z01 HD008737-08/HD/NICHD NIH HHS
Reg. No./Substance:
0/Fertility Agents, Female; 0/Gonadotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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