| History of the ductus arteriosus: 1. Anatomy and spontaneous closure. | |
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MedLine Citation:
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PMID: 20639680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo after the Reformation around 1550. This prompted Harvey's full understanding of the fetal circulation. Botallo did not describe the ductus arteriosus, but in 1564 redescribed the foramen ovale, making his way into the nomina anatomica by mistake. Most authors of the 19th and 20th century believed ductal patency to be passive, and postnatal closure to be an active process, explained by mechanical theories. After the discovery of prostaglandins by Bergstrom and Vane, Coceani proved that ductal patency is maintained by the relaxant action of prostaglandins. |
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Authors:
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Michael Obladen |
Publication Detail:
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Type: Historical Article; Journal Article Date: 2010-07-17 |
Journal Detail:
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Title: Neonatology Volume: 99 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-06-14 Revised Date: 2011-08-11 |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Neonatology, Charité University Medicine, Berlin, Germany. michael.obladen@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anatomy
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history* Ductus Arteriosus / anatomy & histology*, physiology History, 16th Century History, 17th Century History, 18th Century History, 19th Century History, 20th Century Humans Infant, Newborn Prostaglandins / physiology* Religion and Medicine |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins |
| Comments/Corrections | |
Comment In:
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Neonatology. 2011;99(4):311; author response 312
[PMID:
21135567
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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