Document Detail

History of the ductus arteriosus: 1. Anatomy and spontaneous closure.
MedLine Citation:
PMID:  20639680     Owner:  NLM     Status:  MEDLINE    
Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo after the Reformation around 1550. This prompted Harvey's full understanding of the fetal circulation. Botallo did not describe the ductus arteriosus, but in 1564 redescribed the foramen ovale, making his way into the nomina anatomica by mistake. Most authors of the 19th and 20th century believed ductal patency to be passive, and postnatal closure to be an active process, explained by mechanical theories. After the discovery of prostaglandins by Bergstrom and Vane, Coceani proved that ductal patency is maintained by the relaxant action of prostaglandins.
Michael Obladen
Publication Detail:
Type:  Historical Article; Journal Article     Date:  2010-07-17
Journal Detail:
Title:  Neonatology     Volume:  99     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-06-14     Revised Date:  2011-08-11    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Neonatology, Charité University Medicine, Berlin, Germany.
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MeSH Terms
Anatomy / history*
Ductus Arteriosus / anatomy & histology*,  physiology
History, 16th Century
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
Infant, Newborn
Prostaglandins / physiology*
Religion and Medicine
Reg. No./Substance:
Comment In:
Neonatology. 2011;99(4):311; author response 312   [PMID:  21135567 ]

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