| History. Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. By Michael D. Loberg, Malcolm Cooper, Elizabeth Harvey, Patrick Callery, and William Faith. 1976. | |
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MedLine Citation:
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PMID: 6207277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new approach to radiopharmaceutical design is demonstrated, in which small chelating groups capable of binding gamma-emitting radiometals are attached to biologically active molecules, thus producing radiopharmaceuticals based on bifunctional drug and biochemical analogs. The chelating group iminodiacetic acid has been evaluated for this role by examining two N-substituted iminodiacetic acids: methyliminodiacetic acid (MIDA) and N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid (HIDA). Radiochemical and biologic studies showed that both agents were obtained in high radiochemical purity, were stable in vitro and in vivo, and possessed biologic distributions governed almost exclusively by the N-substituted group. These characteristics of 99mTc-labled N-substituted iminodiacetic acids, prepared using an "instant kit" method, provide the basis for a valuable new class of radiopharmaceuticals based on bifunctional drug and biochemical analogs. |
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Authors:
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 25 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-14 Completed Date: 1984-11-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1144-9 Citation Subset: IM; Q |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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History, 20th Century Imino Acids / chemical synthesis* Nuclear Medicine / history* Sarcosine / analogs & derivatives Technetium Technetium Tc 99m Lidofenin |
| Chemical | |
Reg. No./Substance:
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0/Imino Acids; 0/Technetium Tc 99m Lidofenin; 107-97-1/Sarcosine; 142-73-4/iminodiacetic acid; 4408-64-4/strombine; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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