Document Detail


History, Biology, and Health Inequities: Emergent Embodied Phenotypes and the Illustrative Case of the Breast Cancer Estrogen Receptor.
MedLine Citation:
PMID:  23153126     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
How we think about biology-in historical, ecological, and societal context-matters for framing causes of and solutions to health inequities. Drawing on new insights from ecological evolutionary developmental biology and ecosocial theory, I question dominant gene-centric and ultimately static approaches to conceptualizing biology, using the example of the breast cancer estrogen receptor (ER). Analyzed in terms of its 4 histories-societal, individual (life course), tumor (cellular pathology), and evolutionary-the ER is revealed as a flexible characteristic of cells, tumors, individuals, and populations, with magnitudes of health inequities tellingly changing over time. This example suggests our science will likely be better served by conceptualizing disease and its biomarkers, along with changing magnitudes of health inequities, as embodied history-that is, emergent embodied phenotype, not innate biology. (Am J Public Health. Published online ahead of print November 15, 2012: e1-e6. doi:10.2105/AJPH.2012.300967).
Authors:
Nancy Krieger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  American journal of public health     Volume:  -     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Nancy Krieger is a professor with the Department of Society, Human Development, and Health, School of Public Health, Harvard University, Boston, MA.
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