Document Detail

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil.
MedLine Citation:
PMID:  23778668     Owner:  NLM     Status:  MEDLINE    
Candida species are an important cause of bloodstream infections (BSI). To evaluate the epidemiological, clinical and microbiological aspects of two cohorts {1994-1999 [period 1 (P1) ]; 2000-2004 [period 2 (P2) ]} of candidaemic patients, we performed a retrospective analysis from a laboratory-based survey. A total of 388 candidaemias were identified, with an incidence of 0.20/1,000 patient-days and a significant increase in P2 vs. P1 (0.25 vs. 0.15, p = 0.04). Cancer and prior antibiotic use were frequent and Candida albicans was the most prevalent species found (42.4%). Resistance to fluconazole was found in 2.47% of the strains. No differences were observed in the species distribution of Candida during the study periods. In the P2 cohort, there were higher prevalence of elderly individuals, cardiac, pulmonary and liver diseases, renal failure, central venous catheters and antibiotic therapy. In P1, there were higher prevalence of neurological diseases and chemotherapy. The crude mortality was 55.4%. In conclusion, our incidence rates remained high. Furthermore, the distribution pattern of Candida species and the fluconazole resistance profile remained unchanged. Moreover, we found a clear trend of higher prevalence of candidaemia among the elderly and among patients with comorbidities. Finally, it is necessary to discuss strategies for the prevention and control of Candida BSI in Brazil.
Marcos Paulo Wille; Thaís Guimarães; Guilherme Henrique Campos Furtado; Arnaldo Lopes Colombo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Memórias do Instituto Oswaldo Cruz     Volume:  108     ISSN:  1678-8060     ISO Abbreviation:  Mem. Inst. Oswaldo Cruz     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2014-03-14     Revised Date:  2014-05-23    
Medline Journal Info:
Nlm Unique ID:  7502619     Medline TA:  Mem Inst Oswaldo Cruz     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Brazil / epidemiology
Candidemia / epidemiology*,  microbiology
Child, Preschool
Infant, Newborn
Middle Aged
Retrospective Studies
Tertiary Care Centers / statistics & numerical data
Young Adult

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