Document Detail

Historical review of BCG vaccine in Japan.
MedLine Citation:
PMID:  18032829     Owner:  NLM     Status:  MEDLINE    
Bacillus Calmette and Guérin (BCG) was introduced to Japan in 1924 by Kiyoshi Shiga and has been propagated for research purposes ever since propagation is accomplished using a glycerin-bile-potato mixture in the same manner used by Calmette and Guérin. To prepare a stable and safe freeze-dried BCG vaccine, several joint research projects were organized in 1949. At the National Institute of Infectious Diseases (formerly the National Institute of Health), the 172nd passage of BCG from the first culture was freeze-dried in 1961 and was used as the origin of the Japanese BCG strain, Tokyo-172. The Tokyo-172 was registered as an International Reference Strain in 1965 by the World Health Organization. In 1967, a multiple puncture method for BCG vaccination using a plastic cylinder implanted with nine fine needles at one end was introduced to Japan; thereafter, percutaneous administration replaced intradermal injection. The efficacy and adverse reactions of BCG vaccines as well as recent knowledge on the genetic characterization of BCG is also discussed.
Saburo Yamamoto; Toshiko Yamamoto
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Japanese journal of infectious diseases     Volume:  60     ISSN:  1344-6304     ISO Abbreviation:  Jpn. J. Infect. Dis.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-22     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893704     Medline TA:  Jpn J Infect Dis     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  IM    
Department of Microbial and Molecular Pathogenesis, Texas A & M University Health Science Center, College of Medicine, Texas, USA.
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MeSH Terms
BCG Vaccine / administration & dosage,  adverse effects,  history*,  standards
History, 19th Century
History, 20th Century
History, 21st Century
Mycobacterium bovis / genetics
Quality Control
Tuberculosis / history*,  microbiology,  prevention & control
Vaccination / history,  methods
Reg. No./Substance:
0/BCG Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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