Document Detail

Historical perspective on the role of the kidney in acid-base regulation.
MedLine Citation:
PMID:  20013742     Owner:  NLM     Status:  MEDLINE    
Early observations on the acidity of normal urine by J. B. von Helmont (1527-1644) and on urine content of sulfate, phosphate and carbonate by J. J. Berzelius (1779-1848), followed by the studies of Bence Jones (1813-1878) on the connection between food, nutrition and urine acidity, pointed to the role of the kidney in regulation of acid-base status in humans and animals. The next important steps in this field of science were studies by F. Walter (1877) on decreased "alkali" in blood and increased ammonia in the urine of dogs after infusion into their blood of hydrochloric acid, and the observations of B. Naunyn (1939-1925) and O. Minkowski (1853-1931) on the presence of beta-hydroxybutyric acid in urine and on increased ammonia excretion in urine from patients with diabetic coma. Also it was found that patients with uremia had decreased titratable "alkali' in blood (R. von Jaksch 1855-1947) and reduced ability to excrete ammonia (W. W. Palmer and L. J. Henderson 1915). Finally, studies by R. F. Pitts (1908-1977) defined the role of the kidney in reabsorption of bicarbonate in the tubules and linked hydrogen secretion to sodium excretion in the urine.
Miroslaw J Smogorzewski
Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Journal of nephrology     Volume:  22 Suppl 14     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  108-14     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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MeSH Terms
Acid-Base Equilibrium / physiology
Chemistry, Clinical / history
History, 16th Century
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, Medieval
Kidney / physiology*
Nephrology / history
Physiology / history*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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