Document Detail

Historical perspective of pregnancy in chronic kidney disease.
MedLine Citation:
PMID:  17395113     Owner:  NLM     Status:  MEDLINE    
Preeclampsia was first recognized as a cause of proteinuria unique to pregnancy in 1843 and the risk of pregnancy in women with preexisting renal disease was noted in the 1930s. Since then, we have recognized that the majority of women with kidney disease who become pregnant have surviving infants. The exception is women on dialysis whose pregnancies result in only 50% to 75% of infant survival. All women with renal disease are at increased risk for hypertension during pregnancy, but the risk of more rapid than expected progression of renal disease generally occurs in women with serum creatinines greater than 1.4 mg/dL, with an even higher risk in women with serum creatinines greater than 2 mg/dL. Dialysis patients conceive infrequently and have a high frequency of fetal loss and neonatal death. Fertility is restored by renal transplant and guidelines are being developed regarding the ideal timing of pregnancy, the kidney function required for a safe pregnancy, and the use of immunosuppressive drugs in pregnancy.
Susan Hou
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in chronic kidney disease     Volume:  14     ISSN:  1548-5595     ISO Abbreviation:  -     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101209214     Medline TA:  Adv Chronic Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-8     Citation Subset:  IM    
Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA.
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MeSH Terms
Chronic Disease
Creatinine / blood
Fetal Death / etiology
Infertility, Female / etiology
Kidney Diseases / complications*,  therapy
Kidney Transplantation
Menstruation Disturbances / etiology
Pre-Eclampsia / etiology
Pregnancy Complications*
Pregnancy Outcome*
Renal Dialysis / adverse effects
Reg. No./Substance:

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