| Historical perspective on mitochondrial medicine. | |
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MedLine Citation:
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PMID: 20818724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis, uniparental inheritance, intergenomic signaling and its defects, and mitochondrial dynamics. We hope that this historical review also provides an update on mitochondrial medicine, although we fully realize that the speed of progress in this area makes any such endeavor akin to writing on water. |
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Authors:
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Salvatore DiMauro; Caterina Garone |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental disabilities research reviews Volume: 16 ISSN: 1940-5529 ISO Abbreviation: Dev Disabil Res Rev Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319448 Medline TA: Dev Disabil Res Rev Country: United States |
Other Details:
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Languages: eng Pagination: 106-13 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Columbia University Medical Center, College of Physicians & Surgeons, 630 West 168th Street, New York, NY 10032, USA. sd12@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA, Mitochondrial
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history* Developmental Disabilities / history* History, 20th Century Humans Mitochondrial Diseases / history* |
| Grant Support | |
ID/Acronym/Agency:
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HD 32062/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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