Document Detail

Historical perspective: a framework for interpreting pathobiological ideas on human muscle fatigue.
MedLine Citation:
PMID:  8585474     Owner:  NLM     Status:  MEDLINE    
The flow of ideas on the causes of human muscle fatigue appear to have been established in the literature during the last century. Critical analysis had to await innovative experimental designs or techniques. Progress has come particularly from the recognition of inconsistencies, particularly in clinical conditions in which there are alterations in the supply of energy or contractile function. While there is a continuing search for a unique cause of fatigue, much evidence points to there being different causes according to the type of muscular activity or clinical condition. "Nature's experiments" (patients exhibiting isolated defects of function or metabolism) offer unique opportunities for understanding the relative importance of particular levels of metabolic organization or physiological control. Theories of limiting biochemical processes and the Ca- kinetic basis of electromechanical coupling defects are both essentially "single-cell" models of fatigue. Functional requirements appear to determine the diversity of structure and organization of motor units. This would suggest that a "muscle cell population" approach would take into account the consequences of disease altering the number, type of functioning fibers or intrinsic strength of individual fibers. A graphical model is offered to allow a possible interpretation of the cause of fatigue in different forms of exercise and clinical conditions.
R H Edwards; V Toescu; H Gibson
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  384     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-19     Completed Date:  1996-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-94     Citation Subset:  IM; Q    
Department of Medicine, University of Liverpool, United Kingdom.
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MeSH Terms
History, 18th Century
History, 19th Century
History, 20th Century
Muscle Fatigue*

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