| Historical overview of the rationale for the pharmacological use of prolonged-release fampridine in multiple sclerosis. | |
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MedLine Citation:
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PMID: 23146002 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Multiple sclerosis is a progressive demyelinating neurological disease resulting in long-term disability, commonly manifesting in walking impairment and reduced quality of life. The use of the potassium channel blocker fampridine, chemically 4-aminopyridine, as an immediate-release formulation to improve action potential conduction in demyelinated axons was hampered by adverse events, including seizures. The prolonged-release formulation of fampridine (known as modified- or sustained-release fampridine in some countries and dalfampridine extended release in the USA) has a longer apparent half-life and a lower peak plasma concentration versus immediate-release fampridine formulations, sustaining its duration of action and reducing the incidence of adverse events. Prolonged-release fampridine is the first drug specifically licensed to improve walking in patients with multiple sclerosis, and has been shown to consistently improve walking ability in a third of patients. Prolonged-release fampridine Timed-Walk Responders showed both clinically significant improvements in walking speed and in patient-reported walking ability. |
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Authors:
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Oscar Fernandez; Thomas Berger; Hans-Peter Hartung; Norman Putzki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-13 |
Journal Detail:
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Title: Expert review of clinical pharmacology Volume: - ISSN: 1751-2441 ISO Abbreviation: Expert Rev Clin Pharmacol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278296 Medline TA: Expert Rev Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Clinical Neurosciences, Hospital Regional Universitario Carlos Haya, Spain. oscar.fernandez.sspa@juntadeandalucia.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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