Document Detail

Historical declines in tuberculosis in England and Wales: improving social conditions or natural selection?
MedLine Citation:
PMID:  10599006     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: A reinvestigation of the relationship between the decline of tuberculosis and improvement in social conditions in England and Wales during Victorian times. DESIGN: A retrospective study using data published in the annual reports of the Registrar General from 1853 to 1910. MEASURES ASSESSED: The diseases studied, in addition to tuberculosis were dysentery and cholera, including their total and infant mortality. Social conditions were evaluated from earnings and population density per house. RESULTS: Tuberculosis mortality declined at an annual average rate of 1.71% (95% confidence interval [Cl] 0.77-2.63), whereas total mortality, infant mortality and mortality from cholera and dysentery and house population density showed no statistically significant decline over the same period. Real earnings increased by 1.05% (95% CI 0.29-1.81). CONCLUSION: Improving social conditions do not provide the total explanation for the decline in tuberculosis during Victorian times. Other factors, principally natural selection, probably played a role. Part of the current increase in tuberculosis may be caused by effective drug therapy eliminating natural selection.
R P Davies; K Tocque; M A Bellis; T Rimmington; P D Davies
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  3     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-03     Completed Date:  2000-01-03     Revised Date:  2006-06-12    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  1051-4     Citation Subset:  IM    
Tuberculosis Research Unit, Cardiothoracic Centre, Liverpool, United Kingdom.
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MeSH Terms
Cause of Death
England / epidemiology
Infant Mortality
Mortality / trends
Retrospective Studies
Social Conditions*
Socioeconomic Factors
Tuberculosis, Pulmonary / mortality*
Wales / epidemiology
Comment In:
Int J Tuberc Lung Dis. 2000 Sep;4(9):885-6   [PMID:  10985660 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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