Document Detail


Historical control data on prenatal developmental toxicity studies in rabbits.
MedLine Citation:
PMID:  22925216     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits were used for prenatal developmental toxicity studies. The data included maternal reproductive findings at terminal cesarean sections and fetal findings including spontaneous incidences of morphological alterations. No noticeable differences between strains or laboratories were observed in the maternal reproductive and fetal developmental data. The inter-laboratory variations in the incidences of fetal external, visceral, and skeletal alterations seem to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, and terminology of fetal alterations.
Authors:
Makoto Ema; Hiroaki Aoyama; Akihiro Arima; Yuzo Asano; Kazuhiro Chihara; Katsumi Endoh; Sakiko Fujii; Hiroaki Hara; Hashihiro Higuchi; Atsuko Hishikawa; Hitoshi Hojo; Masao Horimoto; Nobuhito Hoshino; Yoshinori Hosokawa; Hiroshi Inada; Ayumi Inoue; Keiichi Itoh; Hiroyuki Izumi; Maki Maeda; Kiyoshi Matsumoto; Seiki Matsuo; Ikuo Matsuura; Hiroshi Mineshima; Yoji Miwa; Hidenori Miyata; Yasumoto Mizoguchi; Nao Nakano; Masato Naya; Hanako Nishizawa; Ken-Ichi Noritake; Hiroko Noyori; Takafumi Ohta; Harutaka Oku; Tatsuya Shimizu; Kazuhiro Shimomura; Kei Shiozawa; Ikuro Takakura; Ryota Tanaka; Tohru Uesugi; Kaoru Yabe; Toshiaki Yamauchi; Ryohei Yokoi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital anomalies     Volume:  52     ISSN:  1741-4520     ISO Abbreviation:  Congenit Anom (Kyoto)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306292     Medline TA:  Congenit Anom (Kyoto)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Congenital Anomalies © 2012 Japanese Teratology Society.
Affiliation:
A Study Group for Historical Control Data on Prenatal Developmental Toxicity Studies in Rabbits.
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