Document Detail

Histoplasma capsulatum yeast cells attach and agglutinate human erythrocytes.
MedLine Citation:
PMID:  15283245     Owner:  NLM     Status:  MEDLINE    
The ability of yeast cells of Histoplasma capsulatum to attach and agglutinate human erythrocytes has been described. This is the first report involving these yeasts in the hemagglutination phenomenon. Results revealed that the yeast cells were able to bind to erythrocytes irrespective of blood groups and to agglutinate them when a high density of yeast cells was used. Assays on the inhibition of yeast attachment to erythrocytes were also performed, using sugar-treated yeast cells. Results indicate that galactose (Gal), mainly the beta-anomer, specially inhibited yeast attachment. Disaccharides (Gal-derivatives) and glycosaminoglycans containing Gal residues, mainly chondroitin sulfate C, promote this type of inhibition. In addition, preliminary data of inhibition assays also involved a probable ionic strength driven mechanism mediated by sialic acid and heparan sulfate, suggesting that yeast binding to erythrocytes could be associated with negative charges of both molecules.
M L Taylor; E Duarte-Escalante; A Pérez; E Zenteno; C Toriello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical mycology     Volume:  42     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-11-16     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
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MeSH Terms
Blood Group Antigens
Cell Adhesion
Chondroitin Sulfates / metabolism
Disaccharides / metabolism
Erythrocyte Aggregation
Erythrocytes / microbiology*
Galactose / metabolism
Glycosaminoglycans / metabolism
Heparitin Sulfate / chemistry
Histoplasma / pathogenicity*
N-Acetylneuraminic Acid / chemistry
Reg. No./Substance:
0/Blood Group Antigens; 0/Disaccharides; 0/Glycosaminoglycans; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate; GZP2782OP0/N-Acetylneuraminic Acid; X2RN3Q8DNE/Galactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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