Document Detail

Histopathology of interscapular brown adipose tissue, thyroid, and pancreas in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats.
MedLine Citation:
PMID:  3952737     Owner:  NLM     Status:  MEDLINE    
The time course of histological changes was studied in rats lethally intoxicated (150 micrograms/kg) with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In addition to TCDD-caused tissue damage described by others, the thyroid, pancreas, and interscapular brown adipose tissue (IBAT) were identified as tissues affected by TCDD. Because histological changes in the thyroid and pancreas occurred late (7 days after dosing), these effects are viewed as secondary due to altered hormonal homeostases. Both light and electron microscopic examination of IBAT identified this tissue as a target in TCDD toxicity. Histological changes in IBAT are characterized by three phases: (1) "fatty" IBAT (Days 1 to 3 after dosing); (2) fat depletion accompanied by glycogen accumulation (Days 4 to 7 after dosing); and (3) complete fat and glycogen depletion together with massive cellular damage (Days 8 to 14), particularly affecting the mitochondria. It is concluded that brown adipose tissue is a primary target in TCDD toxicity. It seems that destruction of brown adipose tissue by TCDD leads to an energy imbalance resulting in reduced oxygen consumption which forces animals to contribute a greater proportion of energy to the maintenance of their body temperature by anaerobic pathways. It is suggested that this less efficient energy utilization is the cause of a wasting syndrome.
K Rozman; D Pereira; M J Iatropoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  82     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-02     Completed Date:  1986-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  551-9     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue, Brown / drug effects*,  pathology
Body Weight / drug effects
Dioxins / toxicity*
Homeostasis / drug effects
Injections, Intraperitoneal
Microscopy, Electron
Pancreas / drug effects*,  pathology
Rats, Inbred Strains
Tetrachlorodibenzodioxin / toxicity*
Thyroid Gland / drug effects*
Reg. No./Substance:
0/Dioxins; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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