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Histopathology and immunohistochemical profile in idiopathic dacryoadenitis.
MedLine Citation:
PMID:  22510006     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: This study deduced the pathological and immunophenotypic features of idiopathic dacryoadenitis, and researched into the possible immune mechanism of this lesion. Methods: Here are 23 lesions of idiopathic lacrimal gland inflammation collected retrospectively, whose histopathologic types were classified based on different characteristics, while the fibrosis degrees were measured. The immunohistochemical staining was performed on tissue sections using monoclonal antibodies against CD20, CD45RO, IL-4 and IFN-γ, the percentages of mononuclear inflammatory cells staining for CD20, CD45RO and the quantities of cells staining positively for IL-4 and IFN-γ were enumerated. Results: Lymphoid follicular and sclerosing lesions are two most common pathological types with different lymphocyte and fibrosis pattern. The proportions of CD20 cells have significant difference between lymphoid follicular (48.6 ± 14.9%) and sclerosing lesions (21.8 ± 12.2%), and the proportions of CD45RO cells are also different in the two types (27.2 ± 6.5% and 43.5 ± 15.1%, respectively). The quantities of lacrimal inflammatory cells staining positively for IL-4 are significantly different in lymphoid follicular (43 ± 27) and sclerosing lesions (11 ± 9), and for IFN-γ are also different (13 ± 8 and 22 ± 16 respectively). Conclusion: Different immune processes exist in idiopathic dacryoadenitis: Th2 mediated B-cell humoral immune response presents in lymphoid follicular type and Th1 mediated cellular immune response presents in sclerosing type.
Authors:
Jie Guo; Jiang Qian; Rui Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current eye research     Volume:  37     ISSN:  1460-2202     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Eye and ENT Hospital of Fudan University , Fen Yang Road, Shanghai , China.
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