| Histopathology findings in common marmosets (Callithrix jacchus Linnaeus, 1758) with chronic weight loss associated with bile tract obstruction by infestation with Platynosomum (Loos, 1907). | |
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MedLine Citation:
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PMID: 18841441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic weight loss in marmosets is often associated with wasting marmoset syndrome (WMS), an important disease that occurs in callitrichid colonies around the world. Even though its etiology is very difficult to determine, particular variables, such as weight loss, diarrhea and alopecia, associated or not with infestation in the pancreatic ducts with Trichospirura leptossoma (Nematoda: Thelazioidea), seem to be linked with the syndrome. This study investigated the histopathology of the lungs, duodenum, liver, gallbladder, extrahepatic bile ducts and pancreatic ducts of six common marmosets (Callithrix jacchus) suffering from severe non-diarrheic weight loss. Three individuals died naturally and the other three were euthanized. Microscopic findings showed the presence of adult flukes (Platynosomum) in the liver. These flukes, which provoke common infection in cats, were also observed inside the gallbladder as well as in the intra and extrahepatic bile ducts in common marmosets. Portal fibrosis was observed in two animals, which developed chronic fibrosing hepatopathy (biliary pattern, grade 3). The disease progresses without diarrhea and without pancreatic lesions or infestation. With the progression, the animals presented with ascending cholangitis, cholestasis and portal fibrosis, sometimes culminating in secondary biliary cirrhosis. Therefore, this infirmity, associated with chronic weight loss in common marmosets, could be another etiological factor linked with WMS. |
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Authors:
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Maria Bernardete Cordeiro Sousa; Adriano Castro Leão; José Flávio Vidal Coutinho; Ana Maria de Oliveira Ramos |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-08 |
Journal Detail:
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Title: Primates; journal of primatology Volume: 49 ISSN: 0032-8332 ISO Abbreviation: Primates Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-23 Completed Date: 2009-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401152 Medline TA: Primates Country: Japan |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
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Departamento de Fisiologia, Universidade Federal do Rio Grande, Caixa Postal, 1511, Natal, RN 59078-970, Brazil. mdesousa@cb.ufrn.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Callithrix* Cholestasis / parasitology, pathology, veterinary* Histological Techniques / veterinary Monkey Diseases / parasitology*, pathology* Trematoda* Trematode Infections / pathology, veterinary* Viscera / parasitology, pathology Weight Loss* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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