Document Detail


Histopathology of experimental vaginal candidosis in immunosuppressed mice.
MedLine Citation:
PMID:  7898516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The histopathology of vaginal candidosis was studied in cyclophosphamide (CY)-immunosuppressed mice. In severely leucopenic animals acutely treated with high doses of CY the fungal inoculation resulted in a massive invasion of the pathogen, which penetrated the whole thickness of vaginal wall and was able to spread further into the surrounding tissues. In some animals, a haematogenous dissemination of the infection was detected. In mice chronically treated with lower doses of CY, moderate leucopenia combined with impaired antifungal granulocyte activity and suppressed cellular immunity resulted in the development of only superficial mycotic lesions. Pathogenetic mechanisms of vaginal candidosis in immunocompetent and immunosuppressed hosts are discussed.
Authors:
V L Bykov; E N Pakhomova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycoses     Volume:  37     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:    1994 Jun-Jul
Date Detail:
Created Date:  1995-04-21     Completed Date:  1995-04-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Affiliation:
Department of Histology, St. Petersburg I. P. Pavlov Medical Institute, Russia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Candidiasis / immunology,  pathology*
Cyclophosphamide / toxicity
Estrus
Female
Immunosuppression
Mice
Mice, Inbred CBA
Neutrophils / pathology
Vaginal Diseases / immunology,  pathology*
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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