| Histopathology of the brain vascular network in moyamoya disease. | |
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MedLine Citation:
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PMID: 6823686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is an unusual vascular network at the base of the brain in patients with moyamoya disease. We detected various histologic lesions in the perforating arteries of 22 patients. Vessels showing rupture ranged from 50 to 530 microns in diameter; they were dilated, some had fibrin deposits in the wall, fragmented elastic laminae and attenuated media. Non-ruptured perforating arteries (diameter 200 to 550 microns) revealed microaneurysm formation, focal fibrin deposits and marked attenuation of the wall thickness with diminution of the elastic lamina. These changes seem to predispose to rupture of perforating arteries. Stenotic changes such as fibrous intimal thickening, collapse of the lumen and thrombosis were detected in 14 out of 22 cases. Morphometric analysis of perforating arteries indicated that arteries showing extreme degrees of stenosis or dilatation were more frequent in the patients with moyamoya disease than in the control cases. Dilative arteries were more frequent in the young patients and stenotic vessels were, in contrast, less frequent in the young patients. |
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Authors:
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M Yamashita; K Oka; K Tanaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 14 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1983 Jan-Feb |
Date Detail:
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Created Date: 1983-03-11 Completed Date: 1983-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 50-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arterial Occlusive Diseases / physiopathology* Brain / blood supply* Carotid Artery, Internal / physiopathology, radiography Cerebral Hemorrhage / complications, physiopathology Child Circle of Willis / pathology, physiopathology, radiography Female Humans Intracranial Aneurysm / complications, physiopathology Male Middle Aged Moyamoya Disease / complications, physiopathology*, radiography |
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