| Histopathology and apoptosis in an animal model of reversible renal injury. | |
| | |
MedLine Citation:
|
PMID: 20181466 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
High adenine phosphate (HAP) diet serves as an animal model of chronic renal failure (RF). Induction of RF and establishment of end organ damage require long exposure periods to this diet. Previously, we have shown that RF is reversible after diet cessation even after protracted administration. In this study, we explored the underlying renal changes and cellular pathways occurring during administration and after cessation of the diet. Kidneys were obtained from rats fed HAP diet for 7 weeks, and from rats fed HAP diet followed a 10 week recovery period on normal diet. The kidneys of HAP diet group were significantly enlarged due to tubular injury characterized by massive cystic dilatation and crystal deposition. Kidney injury was associated with markers of apoptosis as well as with activation of apoptosis related pathways. Diet cessation was associated with a significant reduction in kidney size, tubules diameter, and crystals deposition. The recovery from renal injury was coupled with regression of apoptotic features. This is the first study showing the potential reversibility of long standing RF model, allowing optimal evaluation of uremia-chronic effects. |
| | |
Authors:
|
Mony Shuvy; Abraham Nyska; Ronen Beeri; Suzan Abedat; Anca Gal-Moscovici; Nalini M Rajamannan; Chaim Lotan |
Related Documents
:
|
18248176 - Improved phytate phosphorus utilization by japanese medaka transgenic for the aspergill... 1462356 - Assessment of exposure to parenteral and oral aluminum with and without citrate using a... 6379406 - Early renal brush border membrane adaptation to dietary phosphorus. 8530536 - 1,25-dihydroxyvitamin d3: a novel agent for enhancing wound healing. 11212936 - Effect of dietary concentrate level on body immune response in calves fed a wheat straw... 20510326 - Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-6 fatty... |
Publication Detail:
|
Type: Journal Article Date: 2010-02-23 |
Journal Detail:
|
Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 63 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
|
Languages: eng Pagination: 303-6 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Cardiovascular Research Center, Heart Institute, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intensity-Modulated Radiotherapy Plan Optimisation for Skull Base Lesions: Practical Class Solutions...
Next Document: Risk factors for pneumonia in immunocompromised patients with influenza.