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Histopathology of Scarring Alopecia in Indian Patients.
MedLine Citation:
PMID:  21552105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:: Diagnosis of scarring alopecias (SAs) are challenging, especially when lesions late in the process of development are met with. There is a paucity of literature that profiles the role of histopathology in unscrambling this puzzle, especially in Indian patients. Our aim is to review the histological features of SA in Indian patients and attempt to assign a specific diagnosis. MATERIALS AND METHODS:: We reviewed 37 cases of SA from 2005 to 2009. Sections were assessed for various histological parameters. RESULTS:: There were 18 of 37 cases (49%) of lupus erythematosus, 15 of 37 (41%) lichen planopilaris (LPP), 1 folliculitis, and 3 alopecia areata. The important findings in lupus erythematosus are epidermal atrophy, papillary dermal fibrosis, mucin, peribulbar inflammation, and haphazard spacing of scars. LPP shows an essentially normal epidermis, peri-infundibular infiltrate, and even spacing of scars. Twelve cases had total absence of follicles and yet could be classified based on the connective tissue changes. Alcian blue-periodic acid-Schiff stain highlighted follicular remnants within scars in 9 cases. Three cases of alopecia areata demonstrated peribulbar inflammation, evenly spaced scars, and remnants of catagenic basement membrane. Cases termed as "pseudopelade" clinically were predominantly LPP on histology. CONCLUSIONS:: Histopathology is a dependable tool in identifying the underlying cause in SA. Even in cases that show a complete loss of follicles, it is possible to suggest the etiology based on epidermal and connective tissue changes.
Authors:
Inchara Y K; Rajalakshmi Tirumalae; Reeti Kavdia; Meryl Antony
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-07
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  -     ISSN:  1533-0311     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Departments of *Pathology; and †Dermatology, St. John's Medical College and Hospital, Bangalore, Karnataka, India.
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