Document Detail

Histopathological study of apparently normal skin of patients with leprosy.
MedLine Citation:
PMID:  16533232     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several clinical and laboratory observations point to the possible microscopical affection of normal-looking skin in leprosy. OBJECTIVE: This study was carried out to verify the microscopical affection of apparently normal-looking skin in different types of leprosy. PATIENTS AND METHODS: The study included 50 patients with different clinical types of leprosy. Biopsies from both skin lesions and normal-looking skin were obtained from each patient and examined for microscopical evidence of leprosy. RESULTS: Microscopical affection of normal-looking skin was detected in 52% of our cases, with higher incidence of affection towards the lepromatous end of the disease. CONCLUSION: Our findings underscore that the incidence of microscopical affection of normal-looking skin in leprosy is much higher on the lepromatous end of the spectrum of leprosy than on the tuberculoid end; during treatment, the leprosy granulomas may disappear from the normal skin before the clinical lesions. Moreover, the microscopic picture of indeterminate leprosy can be observed in the normal-looking skin of patients with tuberculoid leprosy or lepromatous leprosy, and this description appears not to be confined to the entity known as indeterminate leprosy.
Mohammad A El-Darouti; Soliman Hussein; Salonaz A Marzouk; Naglaa Nabil; Nahla S Hunter; Duaa Mahgoub; Nermine H El-Eishi; Mona R E Abdel-Halim
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  45     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-07-06     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-6     Citation Subset:  IM    
Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
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MeSH Terms
Leprostatic Agents / therapeutic use
Leprosy, Borderline / drug therapy,  pathology*
Leprosy, Lepromatous / drug therapy,  pathology*
Leprosy, Tuberculoid / drug therapy,  pathology*
Middle Aged
Skin / pathology*
Skin Diseases, Bacterial / drug therapy,  pathology*
Sweat Glands / pathology
Reg. No./Substance:
0/Leprostatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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