Document Detail

Histopathological studies of a case of cytomegalovirus retinochoroiditis.
MedLine Citation:
PMID:  1325007     Owner:  NLM     Status:  MEDLINE    
A case of cytomegalovirus (CMV) retinochoroiditis initially misdiagnosed as fungal endophthalmitis is reported. An 83-year-old man who was suspected of having cholangiocarcinoma presented uveitis in both eyes. Candida endophthalmitis was suspected on the basis of ophthalmic findings and past history, which included systemic corticosteroid administration and intravenous hyperalimentation. Intravenous treatment with miconazole was not effective. At autopsy, 3 months after the initial ophthalmological examination, the right eye was enucleated and examined histologically and histochemically. Light microscopic examination showed extensive retinal necrosis and numerous cytomegalic cells, so-called owl's eye cells, with intranuclear and intracytoplasmic inclusion bodies. CMV particles were seen by electron microscopy, and CMV-infected cells were observed by immunohistochemical staining by the direct method with fluorescein-labeled antibodies. These findings indicate that in suspected cases of fungal endophthalmitis various tests should also be carried out for CMV.
T Nishiuchi; H Shiota; H Ishimaru; T Katayama; Y Bando; H Tani; C Shimoe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  36     ISSN:  0021-5155     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-01     Completed Date:  1992-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Department of Ophthalmology, School of Medicine, Tokushima University, Japan.
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MeSH Terms
Aged, 80 and over
Antigens, Viral / analysis
Chorioretinitis / microbiology,  pathology*
Cytomegalovirus / immunology,  ultrastructure
Cytomegalovirus Infections / pathology*
Eye Infections, Viral / immunology,  pathology*
Fluorescent Antibody Technique
Fundus Oculi
Immunoenzyme Techniques
Pigment Epithelium of Eye / microbiology,  ultrastructure
Retina / microbiology,  ultrastructure
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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