| Histopathological and immunohistochemical studies of infective dermatitis associated with HTLV-I. | |
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MedLine Citation:
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PMID: 15701589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infective dermatitis associated with HTLV-I (IDH) is a chronic, recurrent, exudative eczema occurring in childhood which is considered to be a risk factor for the development of lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis. Skin biopsies from 19 patients with IDH were studied histologically and immunohistochemically using the following antibodies: anti-CD3, CD45RO, CD20, CD79a, CD4, CD8, CD56, CD57, TIA-1, granzyme-B, and perforin. A chronic dermatitis similar to atopic and seborrheic dermatitis was observed in 15 cases, whereas architectural aspects mimicking mycosis fungoides were observed in the remaining four. The infiltrate consisted predominantly of CD8+ lymphocytes and of CD57+ cells in the dermis and epidermis. TIA-1 and granzyme-B were expressed in 15/18 cases and 5/19 cases at the proportion of < or = 15% and < or = 3%, respectively. All cases were negative for perforin and CD56. Like other dermatites, histologically IDH may represent a benign simulator of mycosis fungoides. IDH shows a predominance of CD8+ cells and a low percentage of cells with cytotoxic granules, indicating that most CD8+ lymphocytes are not activated. These findings differ from the immunohistochemical pattern of atopic and seborrheic dermatitis, possibly representing additional means of differentiation between IDH and these dermatites. The distribution of CD57+ cells suggests that they play a role in the inflammatory process. |
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Authors:
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Achiléa L Bittencourt; Maria de Fátima Oliveira; Carlos Brites; Johan Van Weyenbergh; Maria das Graças da Silva Vieira; Iguaracyra Araújo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: 15 ISSN: 1167-1122 ISO Abbreviation: Eur J Dermatol Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-02-09 Completed Date: 2005-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: France |
Other Details:
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Languages: eng Pagination: 26-30 Citation Subset: IM |
Affiliation:
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Department of Pathology and Dermatology, Hospital Universitário Prof. Edgard Santos, Federal University of Bahia, CPqGM-FIOCRUZ Salvador, Bahia, Brazil. achilea@uol.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Dermatitis / immunology, pathology*, virology* Female HTLV-I Infections / immunology, pathology* Humans Immunohistochemistry Lymphocytes Male |
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