Document Detail

Histopathological, histomorphometrical, and immunohistochemical biomarkers in flounder (Platichthys flesus) from the southern Baltic Sea.
MedLine Citation:
PMID:  22118815     Owner:  NLM     Status:  Publisher    
Flounder (Platichthys flesus), collected in late fall of 2009 from four coastal sites in the southern Baltic Sea including the Gulf of Gdańsk (GoG), were investigated for a suite of biomarkers of contaminant effects. The biomarkers included liver histopathologies, which were diagnosed and assessed using commonly applied lesion categories, the size and density of melano-macrophage aggregates (MMAs), expression of proliferating cell nuclear antigen (PCNA) and of cytochrome P450 1A (CYP1A) in liver as well as the size and density of MMAs and density of Perls'-positive cells in the spleen. The prevalence of liver lesions differed among the sites. Most frequently occurring were non-specific and early toxicopathic non-neoplastic lesions. Mean MMA size was in the range of 264-519μm(2) and 717-2137μm(2) in liver and spleen, respectively, and density was in the range of 6-13 and 15-26MMAmm(-2), respectively. Mean density of PCNA-positive hepatocytes was in the range of 300-1281cellsmm(-2). These histomorphometrical biomarkers correlated positively with the muscle Hg, Σ(7)PCB, and ΣDDT residues and negatively with the indices of general liver condition. They showed significant differences between the sites, which were in line with the spatial prevalence of liver lesions and CYP1A induction. Overall, the biomarker responses were more pronounced in the GoG sites in comparison to those outside the Gulf, which confirms some earlier results and broadens the knowledge of contaminant effects in the Polish coastal zone of the Baltic Sea.
Henryka Dabrowska; Teresa Ostaszewska; Maciej Kamaszewski; Agnieszka Antoniak; Lukasz Napora-Rutkowski; Orest Kopko; Thomas Lang; Nicolai F Fricke; Kari K Lehtonen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-23
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  -     ISSN:  1090-2414     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
National Marine Fisheries Research Institute, Department of Food and Environmental Chemistry, KoŁŁątaja 1, 81-332 Gdynia, Poland.
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