Document Detail


Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases.
MedLine Citation:
PMID:  2355235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.
Authors:
B Meurers; W Kohlhepp; R Gold; E Rohrbach; H G Mertens
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  237     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-20     Completed Date:  1990-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  IM    
Affiliation:
Neurologische Universitätsklinik und Poliklinik, Würzburg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Central Nervous System / pathology*
Female
Humans
Lyme Disease / complications,  pathology*
Male
Middle Aged
Nervous System Diseases / etiology,  pathology*
Peripheral Nerves / pathology*
Vasculitis / etiology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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