| Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies. | |
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MedLine Citation:
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PMID: 23159117 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ. |
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Authors:
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Young-Ah Cho; Hye-Jung Yoon; Jae-Il Lee; Sam-Pyo Hong; Seong-Doo Hong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology and oral radiology Volume: 114 ISSN: 2212-4411 ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101576782 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 785-91 Citation Subset: D; IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Clinical Lecturer, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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