Document Detail

Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies.
MedLine Citation:
PMID:  23159117     Owner:  NLM     Status:  In-Data-Review    
The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.
Young-Ah Cho; Hye-Jung Yoon; Jae-Il Lee; Sam-Pyo Hong; Seong-Doo Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  114     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  785-91     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Clinical Lecturer, Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
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