Document Detail

Histopathological examination of specimens removed during directional coronary atherectomy in patients presenting with crescendo angina show mural thrombus.
MedLine Citation:
PMID:  8506189     Owner:  NLM     Status:  MEDLINE    
Thrombus formation over a fissured coronary atheromatous plaque has been shown by post mortem histological examination to be the pathophysiological mechanism responsible for myocardial ischaemia in those patients who died following a crescendo pattern of angina. Histological examination of plaques responsible for a crescendo pattern of angina in patients who do not die has not been available until recently. We describe two patients who presented with a crescendo pattern of angina. A new technique of coronary revascularization, directional coronary atherectomy, produced symptomatic relief and resolution of myocardial ischaemia. Histological examination of material from the stenosis responsible for their myocardial ischaemia, obtained using this technique, confirmed thrombus formation overlying a fissured atheromatous plaque.
C M Bellamy; E D Grech; M T Ashworth; D R Ramsdale
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  69     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-07-07     Completed Date:  1993-07-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  112-4     Citation Subset:  IM    
Cardiology Research Department, NHS Trust, Liverpool, UK.
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MeSH Terms
Angina Pectoris / pathology*,  radiography
Atherectomy, Coronary*
Coronary Angiography
Coronary Thrombosis / pathology*,  radiography
Coronary Vessels / pathology*
Middle Aged

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