| Histopathological evolution of a cutaneous myxofibrosarcoma. | |
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MedLine Citation:
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PMID: 18638228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 54-year-old woman presented with a 6-month history of a tender and swollen plaque appearing as a panniculitis affecting the left pretibial area. The initial histopathology revealed dermal and subcutaneous inflammation with interstitial histiocytes and mucinosis suggestive of either granuloma annulare or necrobiosis lipoidica. Over the subsequent 6 months the plaque grew progressively, despite treatment with topical corticosteroids under occlusion. Distal to the plaque reduced sensation developed in the limb. Biopsies of the nodular areas now revealed a dense dermal infiltrate of atypical spindle cells within a prominent myxoid stroma and a pleomorphic multinucleated epithelioid cell component. These features were those of an intermediate grade myxofibrosarcoma. This soft-tissue sarcoma may initially masquerade clinically as a panniculitis and a granulomatous process on biopsy as in our patient, leading to a delay in surgical therapy. |
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Authors:
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Rhonda A Kwong; Steven Kossard |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Australasian journal of dermatology Volume: 49 ISSN: 1440-0960 ISO Abbreviation: Australas. J. Dermatol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0135232 Medline TA: Australas J Dermatol Country: Australia |
Other Details:
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Languages: eng Pagination: 169-72 Citation Subset: IM |
Affiliation:
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Skin and Cancer Foundation, Darlinghurst, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Female Fibroma / pathology*, surgery Fibrosarcoma / pathology*, surgery Humans Lymphatic Metastasis Middle Aged Skin Neoplasms / pathology*, surgery |
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