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Histopathological effects of short and long-term treatment of Orchis antolica crude root extract on female albino rats fertility and pregnancy.
MedLine Citation:
PMID:  22816178     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The present study has investigated the effects of Orchis antolica (dose of 400 mg/kg/Body Wight) on female rats reproductive system for two time periods 4 and 12 weeks. Forty adult female Sprague-Dawley rats were divided into two treatment and two control groups of 10 rats each. The two treated groups received 400 mg/kg/body weight of Orchis antolica for two periods of 4 and 12 weeks. Female rats were allowed mating with untreated males when treatment ended. Pregnancy parameters such as: total number of pregnancy, body weight, reproductive organ weight, number of implantation sites, number of resorption sites and number of viable fetuses. The significance of these results was calculated using student's "t" and Chi- square tests. Treatment with Orchis antolica for 4 weeks did not have any significant effects on most parameters investigated except for a slight increase in the relative ovarian and embryo weights. Orchis antolica for 12 weeks induces a significant increased in the percentage of pregnancies and the number of implantation sites when compared with controls. Further, an increase in ovarian weights and in viable fetuses count was also observed. Histological sections of treated female ovaries were found to have an empty blood vessels within the cortical and modularly regions. We also noted an increased in the developing follicles at primary and secondary stages in addition to an absence of degenerative areas and increased cellularity in medulla. Long-term treatment with Orchis antolica might lead to diversified positive effects on fertility and pregnancy in female rats.
Authors:
Nabil A Khouri; Haytham Daradka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  15     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Jordan.
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