Document Detail

Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals.
MedLine Citation:
PMID:  3940265     Owner:  NLM     Status:  MEDLINE    
The effects of exogenously administered testosterone were evaluated in a group of 19 female to male transsexuals who underwent bilateral salpingo-oophorectomy after a variable period of androgen therapy. The findings were compared to those in an age-matched group of 12 patients who underwent pelvic surgery for nonendocrine reasons. The most significant findings in the 19 androgen-treated female transsexuals was the finding of enlarged or borderline enlarged ovaries in 5 subjects. In addition, we found multiple cystic follicles in 17 patients (89.5%), diffuse ovarian stromal hyperplasia in 16 patients (84.2%), collagenization of the outer cortex in 13 patients, and 4) luteinization of stromal cells in 5 patients (26.3%). Findings consistent with polycystic ovaries were thus present in 13 of the 19 patients based on the presence of 3 of the above 4 findings. The data suggest that increased blood levels and presumably increased ovarian concentrations of testosterone may produce the morphological features of polycystic ovarian disease.
W Futterweit; L Deligdisch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  62     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  AIM; IM    
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MeSH Terms
Hirsutism / etiology
Middle Aged
Ovary / drug effects,  pathology
Polycystic Ovary Syndrome / pathology
Testosterone / therapeutic use*
Transsexualism / pathology*
Reg. No./Substance:

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