Document Detail

Histopathological changes of vocal folds induced by chronic pollutant exposure: an experimental study.
MedLine Citation:
PMID:  16301099     Owner:  NLM     Status:  MEDLINE    
Calcium carbonate (CaCO(3)) particles, the main component of chalk, are an important pollutant in the Brazilian school environment. However, there are few reports of the effect of this pollutant in the vocal folds and its influence in voice disorder in the literature. METHODS: Thirty rats (Wistar), randomly divided into two groups, the control group and the experimental group, were submitted to air or to CaCO(3) inhalation, respectively, during 15, 30, and 90 days. Then, the larynx region was dissected and embedded in paraffin, and 5-mum sections were obtained for microscopic analysis. RESULTS: No histopathological alteration was found on the vocal folds in the control group. In the experimental group, a moderate chronic inflammatory infiltrate, characterized by macrophage cells, was found in the vocal folds after 30 and 90 days of the CaCO(3) inhalation. CONCLUSIONS: This study suggests that the inhalation of pollutant particles, such as CaCO(3), induces inflammatory alterations in the larynx; this can affect the vibration of the vocal folds, which influence vocal function.
Fabiana Carla Marcelino; Denise Tostes Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of voice : official journal of the Voice Foundation     Volume:  19     ISSN:  0892-1997     ISO Abbreviation:  J Voice     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712262     Medline TA:  J Voice     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Department of Speech Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octavio Pinheiro Brisolla, 9-75 CEP 17012-901, Bauru, São Paulo, Brazil.
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MeSH Terms
Air Pollutants / adverse effects*
Air Pollution / adverse effects*
Calcium Carbonate / adverse effects*
Random Allocation
Rats, Wistar
Vocal Cords / drug effects*,  pathology
Voice Quality / drug effects*
Reg. No./Substance:
0/Air Pollutants; 471-34-1/Calcium Carbonate

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