Document Detail

Histopathological changes during experimental infections of calves with Cooperia punctata.
MedLine Citation:
PMID:  15153289     Owner:  NLM     Status:  MEDLINE    
Eleven male two-month-old Holstein calves were used to determine the pathological changes induced by a Cooperia punctata infection. After weaning, ten calves received a single oral dose of 45,000 C. punctata infective larvae. One calf remained as a non-infected control. Groups of two calves were killed on days 7, 14, 21, 28 and 35 post-infection (p.i.) for determination of worm burdens and histopathological evaluation. The small intestine was sub-divided into three sections of approximately equal length, and representative samples of mucosa were fixed in 10% formalin, cut, and stained with haematoxylin-eosin. Samples of intestinal contents and mucosal digests were taken and fixed in 10% formalin for an estimation of total worm burdens. An increase in the number of adult parasites and a decrease in the number of larvae were observed with time (P<0.001). A higher concentration of worms was found in the first segment of the small intestine during the five weeks of observation. Histology showed larvae in the intestinal mucosa on day 7 p.i., with a discrete increase in the cellular response. Adult worms and a marked cellular infiltrate with eosinophils and neutrophils were present on day 21 p.i., and these persisted until day 35 p.i. Microcysts resulting from worm destruction were observed from day 21 p.i.
R R Rodrigues; S M Gennari; J L Guerra; M B Contieri; A L Abdalla; D M S S Vitti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of helminthology     Volume:  78     ISSN:  0022-149X     ISO Abbreviation:  J. Helminthol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-21     Completed Date:  2004-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985115R     Medline TA:  J Helminthol     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Centro de Energia Nuclear na Agricultura, Avenida Centenário 303, CEP 13.400-970, Universidade de São Paulo, Piracicaba, Brazil.
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MeSH Terms
Cattle Diseases / parasitology,  pathology*
Intestinal Mucosa / parasitology,  pathology
Intestine, Small / parasitology,  pathology
Trichostrongyloidiasis / parasitology,  pathology*
Trichostrongylus / growth & development,  isolation & purification

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