Document Detail

Histopathological and bacteriological findings in prurigo nodularis.
MedLine Citation:
PMID:  9059678     Owner:  NLM     Status:  MEDLINE    
Prurigo nodularis is a chronic disease with unknown aetiology. Biopsy specimens of 43 patients with prurigo nodularis were taken for histopathological and mycobacteriological analyses. By conventional histopathology, 25 (58%) samples, and by immunostaining for S100 protein, 31 (72%) samples had changes relevant to prurigo nodularis. Twelve (28%) of the samples were positive for acid fast bacilli in tissue staining by Ziehl-Neelsen technique, including 4 of the 6 samples also positive for mycobacteria in cultivation. The results verified the usefulness of S100 staining in detection of neural hyperplasia in dermal nerves, a feature regarded as diagnostic for prurigo nodularis. They also indicated that atypical mycobacteria may be a contributing factor in prurigo nodularis.
J O Mattila; M Vornanen; M L Katila
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  77     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-23     Completed Date:  1997-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
Department of Dermatology, Kuopio University Hospital, Finland.
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MeSH Terms
Aged, 80 and over
Middle Aged
Mycobacteria, Atypical / isolation & purification*
Peripheral Nerves / pathology
Prurigo / microbiology*,  pathology*
Skin / innervation

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