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Histopathological aspects of cardiac biopsy in pediatric patients with dilated cardiomyopathy.
MedLine Citation:
PMID:  20854285     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:  Dilated cardiomyopathy (DCM) is a heart muscle disease with cardiac dysfunction and a heterogenous disorder. This disease may show various histopathological aspects of the myocardium, but little is known about these in children. Methods:  Histopathological findings of endomyocardial biopsy from 20 pediatric patients with DCM were analyzed and compared with those in adult patients. Results:  Advanced histopathology, including myocytolysis and/or fragmentation of muscle bundles, was frequently observed in patients with poor prognosis. Patchy fibrosis was predominantly demonstrated in the pediatric patients, whereas perivascular fibrosis was mostly observed in the older adults. The myocarditic index, assessed in terms of the findings of fibrosis, size variation of myocytes, disarrangement of muscle bundles and mononuclear cell infiltration was higher in the pediatric patients than in the older adults (P < 0.05). Bizarre myocardial hypertrophy with disorganization, which tends to be frequently demonstrated in hypertrophic cardiomyopathy, was revealed in 30% of the pediatric patients, whereas it was disclosed in none of the older adult patients (P < 0.05). Conclusion:  These results suggest that the major pathogenetic factors of DCM in children may be different from those in adults.
Authors:
Toshio Nishikawa; Kenta Uto; Saeko Kanai; Hideaki Oda; Shunji Kawamura; Toshio Nakanishi; Nobuhisa Hagiwara; Shin-Ichiro Morimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  53     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  350-3     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
Affiliation:
Departments of Surgical Pathology Pathology Cardiology, School of Medicine Pediatric Cardiology School of Medicine, Tokyo Women's Medical University, Tokyo Department of Medicine, Fujita Health University, Toyoake, Japan.
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