Document Detail


Histopathological alterations of the parathyroid glands in haemodialysis patients with secondary hyperparathyroidism refractory to cinacalcet hydrochloride.
MedLine Citation:
PMID:  21565858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cinacalcet treatment for secondary hyperparathyroidism (SHPT) has demonstrated parathyroid size regression and morphological changes, such as cystic degeneration and hypovascularisation, on ultrasonography. However, there have been very few reports regarding the histopathological alterations of hyperplastic parathyroid glands in patients with SHPT after administration of cinacalcet. The aim of this study was to elucidate the effects of cinacalcet for histopathological alterations on the parathyroid glands.
METHODS: A total of 92 hyperplastic parathyroid glands were obtained from 24 dialysis patients with severe SHPT who underwent total parathyroidectomy and were enrolled in this study. Patients were divided into those treated with and without cinacalcet (cinacalcet group and conventional group, respectively; both n=12). The areas of oxyphil cells, cystic degeneration, haemorrhagic changes and haemosiderin deposition were assessed semiquantitatively.
RESULTS: Total maximal parathyroid gland weight and maximal-to-minimal parathyroid gland weight ratio were significantly higher in the cinacalcet group compared with the conventional group (1798.7±1658.3 mg vs 764.2±471.1 mg, p=0.018, 15.8±13.9 vs p=0.047, 6.6±4.2, respectively). Significant increases were observed in oxyphil cell area (61.7%±17.1% vs 36.7%±15.6%, p=0.001) and haemosiderosis score (1.50±1.24 vs 0.42±0.51, p=0.029) in the former rather than the latter group.
CONCLUSIONS: These results suggest that cinacalcet may induce specific qualitative alterations of hyperplastic parathyroid glands in patients with severe SHPT.
Authors:
Keiichi Sumida; Michio Nakamura; Yoshifumi Ubara; Yuji Marui; Kiho Tanaka; Kenmei Takaichi; Shinji Tomikawa; Naoko Inoshita; Kenichi Ohashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-12
Journal Detail:
Title:  Journal of clinical pathology     Volume:  64     ISSN:  1472-4146     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-19     Completed Date:  2011-10-19     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  756-60     Citation Subset:  AIM; IM    
Affiliation:
Nephrology Center, Toranomon Hospital, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cell Count
Drug Resistance
Female
Humans
Hyperparathyroidism, Secondary / drug therapy,  etiology,  pathology*
Hyperplasia
Kidney Failure, Chronic / complications,  drug therapy,  pathology
Male
Middle Aged
Naphthalenes / pharmacology,  therapeutic use*
Organ Size
Oxyphil Cells / drug effects,  pathology
Parathyroid Glands / drug effects,  metabolism,  pathology*
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Naphthalenes; UAZ6V7728S/cinacalcet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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