| Histopathological alterations and functional brain deficits after transient hypoxia in the newborn rat pup: a long term follow-up. | |
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MedLine Citation:
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PMID: 14572448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess temporal brain deficits consecutive to severe birth hypoxia, newborn rats were exposed for 20 min to 100% N2. This treatment induced a long-term growth retardation and a delayed, but only transient, neuronal loss (approximately 25%) in the CA1 hippocampus and parietal cortex, starting from 3 days and peaking at 6 days post-hypoxia. The expression profiles of various apoptosis-regulating proteins (including Bcl-2, Bax, p53 and caspase-3) were well correlated to the alterations of nuclear morphology depicted by 4,6-diamidino-2-phenylindole (DAPI). Whereas they confirmed a gradual histological recovery, specific DNA fragmentation patterns suggested that birth hypoxia may transiently reactivate the developmental programme of neuronal elimination. Although they successfully achieved various behavioral tests such as the righting reflex, negative geotaxis, locomotor coordination, and the eight-arm maze tasks, both developing and adult hypoxic rats were repeatedly slower than controls, suggesting that birth hypoxia is associated to moderate but persistent impairments of functional capacities. |
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Authors:
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Stéphanie Grojean; Henri Schroeder; Grégory Pourié; Christiane Charriaut-Marlangue; Violette Koziel; Didier Desor; Paul Vert; Jean-Luc Daval |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurobiology of disease Volume: 14 ISSN: 0969-9961 ISO Abbreviation: Neurobiol. Dis. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-23 Completed Date: 2004-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 265-78 Citation Subset: IM |
Affiliation:
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INSERM EMI 0014, Université Henri Poincaré, Nancy, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Brain / metabolism, pathology*, physiopathology* Cell Count / methods Follow-Up Studies Hypoxia, Brain / metabolism, pathology*, physiopathology* Maze Learning / physiology Motor Activity / physiology Rats Rats, Sprague-Dawley Time Factors |
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