Document Detail

Histopathological alterations and functional brain deficits after transient hypoxia in the newborn rat pup: a long term follow-up.
MedLine Citation:
PMID:  14572448     Owner:  NLM     Status:  MEDLINE    
To assess temporal brain deficits consecutive to severe birth hypoxia, newborn rats were exposed for 20 min to 100% N2. This treatment induced a long-term growth retardation and a delayed, but only transient, neuronal loss (approximately 25%) in the CA1 hippocampus and parietal cortex, starting from 3 days and peaking at 6 days post-hypoxia. The expression profiles of various apoptosis-regulating proteins (including Bcl-2, Bax, p53 and caspase-3) were well correlated to the alterations of nuclear morphology depicted by 4,6-diamidino-2-phenylindole (DAPI). Whereas they confirmed a gradual histological recovery, specific DNA fragmentation patterns suggested that birth hypoxia may transiently reactivate the developmental programme of neuronal elimination. Although they successfully achieved various behavioral tests such as the righting reflex, negative geotaxis, locomotor coordination, and the eight-arm maze tasks, both developing and adult hypoxic rats were repeatedly slower than controls, suggesting that birth hypoxia is associated to moderate but persistent impairments of functional capacities.
Stéphanie Grojean; Henri Schroeder; Grégory Pourié; Christiane Charriaut-Marlangue; Violette Koziel; Didier Desor; Paul Vert; Jean-Luc Daval
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of disease     Volume:  14     ISSN:  0969-9961     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2004-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-78     Citation Subset:  IM    
INSERM EMI 0014, Université Henri Poincaré, Nancy, France.
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MeSH Terms
Animals, Newborn
Brain / metabolism,  pathology*,  physiopathology*
Cell Count / methods
Follow-Up Studies
Hypoxia, Brain / metabolism,  pathology*,  physiopathology*
Maze Learning / physiology
Motor Activity / physiology
Rats, Sprague-Dawley
Time Factors

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