| Histopathological abnormalities in ocular blood vessels of CADASIL patients. | |
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MedLine Citation:
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PMID: 15289148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess histopathological findings in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). DESIGN: Case reports and histopathological evaluation of enucleated eyes. METHODS: Four eyes from two CADASIL patients were enucleated at autopsy and prepared for histopathological analysis using light and electron microscopy. RESULTS: Thickening of arterial walls with fibrosis, eosinophilic Periodic acid Schiff-positive basement membrane material and loss of vascular smooth muscle cells (VSMC) in the central retinal artery and its branches, the leptomeninges, the ocular adnexa, and the optic disk were observed. On electron microscopy, numerous deposits of granular, osmiophilic material in arterial walls as well as VSMC and pericyte degeneration were noted. In contrast to retinal vessels, the choroid was not affected. CONCLUSION: Our findings suggest a differential involvement of small blood vessels in CADASIL, depending on the angioarchitecture and support autopsy data of nervous tissue describing that loss of VSMCs is most pronounced in tissues depending on blood-tissue barriers. |
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Authors:
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Christos Haritoglou; Jan P Hoops; Fritz H Stefani; Parviz Mehraein; Anselm Kampik; Martin Dichgans |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 138 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 302-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany. christos.haritoglou@ak-i.med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bruch Membrane
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ultrastructure Dementia, Multi-Infarct / pathology* Eosinophils / pathology Fibrosis Humans Male Middle Aged Muscle, Smooth, Vascular / pathology Pedigree Pericytes / pathology Pigment Epithelium of Eye / ultrastructure Retinal Artery / ultrastructure* Retinal Diseases / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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