Document Detail

Histopathologic study of partial hydatidiform moles and DNA triploid placentas.
MedLine Citation:
PMID:  7921197     Owner:  NLM     Status:  MEDLINE    
Sixty-two placentas with a triploid DNA content, which were analyzed by flow cytometry using paraffin-embedded tissues, were histologically investigated. These placentas were histologically classified as follows: 51 partial hydatidiform moles (PM), two hydropic abortuses and nine non-hydropic placentas. The DNA indices of the triploid peaks were between 1.41 and 1.60. Histologically, two populations of normal and edematous villi, vesicular villous edema with cistern formation, focal syncytiotrophoblastic hyperplasia with vacuolation, and villous scalloping with trophoblastic inclusion were almost always observed in the PM, but no single pathologic feature was specific for PM. The two entities, PM and triploid placenta, overlapped. Not all triploid gestations are PM and not all PM moles are triploid as shown in previously reported diploid or tetraploid PM. Although no patient with triploid PM developed persistent disease in this series, follow up of triploid PM is required as long as its true biological potential remains unclear. Flow cytometry is a reliable aid in the diagnosis of PM.
M Fukunaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  44     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-11-15     Completed Date:  1994-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  528-34     Citation Subset:  IM    
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Abortion, Spontaneous / pathology
Chorionic Gonadotropin / urine
Follow-Up Studies
Hydatidiform Mole / genetics*,  pathology*
Middle Aged
Placenta / chemistry*
Uterine Neoplasms / genetics*,  pathology*
Reg. No./Substance:
0/Chorionic Gonadotropin

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