| Histopathologic limbus evolution after alkaline burns. | |
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MedLine Citation:
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PMID: 17893531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study the histopathologic evolution of the corneal limbus after alkaline burns according to the clinical severity and therapy used. METHODS: A prospective study of 15 eyes from 12 patients (9 men and 3 women) with moderate and severe alkaline burns was performed. All patients were divided into 2 groups in accordance with the clinical ocular severity and the therapy that was used: medical therapy, amniotic membrane transplantation (AMT), autologous limbal transplantation (ALT), and ALT combined with AMT (ALT + AMT). Biopsies were obtained from affected limbal areas immediately after the ocular burn and 9 months later. RESULTS: Limbal regeneration was limited to small areas in patients with moderate burns treated with medical therapy; in contrast, the limbal structure showed significant stromal and epithelial regeneration in patients with moderate burns treated with AMT. There was an important stromal regeneration with an incomplete reepithelialization in patients with severe burns treated with AMT. Patients treated with ALT showed a good reepithelialization with a defective stromal regeneration. Epithelial and stromal regeneration was notable in patients with severe burns treated with ALT + AMT. CONCLUSIONS: In patients with moderate alkaline burns, AMT improved both limbal stromal and epithelial regeneration more effectively than medical therapy. In patients with severe burns, the best reepithelialization and stromal regeneration were obtained with ALT + AMT. |
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Authors:
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José Santiago López-García; Luis Rivas Jara; Isabel García-Lozano; Juan Murube |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-25 Completed Date: 2008-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 1043-8 Citation Subset: IM |
Affiliation:
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Ophthalmology Service, Hospital Cruz Roja, Madrid, Spain. docsantilopez@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkalies Amnion / transplantation Burns, Chemical / classification, pathology*, therapy Double-Blind Method Epithelial Cells / physiology Eye Burns / chemically induced*, classification, pathology, therapy Female Humans Limbus Corneae / pathology* Male Prospective Studies Regeneration / physiology Stem Cell Transplantation Stem Cells / pathology* Wound Healing* |
| Chemical | |
Reg. No./Substance:
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0/Alkalies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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