| Histopathologic findings of lung vessels in five children with primary pulmonary hypertension. | |
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MedLine Citation:
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PMID: 8036624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A histopathologic study was carried out on pulmonary vessels of lung tissues from 5 children with primary pulmonary hypertension (PPH), in whom diagnosis was made on the basis of cardiac catheterization. Histological sections of lung were obtained in 4 patients by open lung biopsy and in one patient by closed needle necropsy soon after death. In all cases the vascular diseases were classified as grade 6 of the Heath-Edwards. Morphologic studies of small pulmonary arteries revealed medial hypertrophy (41.0%), intimal cellular proliferation (2.5%), intimal fibroelastic proliferation (36.9%) and medial destructive changes (19.6%) such as dilatation lesions, plexiform lesions, arteritis, or fibrinoid necrosis. Index of pulmonary vascular disease (IPVD) was 1.6 to 3.4 (mean 2.5). The advancement of these pulmonary changes sufficiently explains the extremely poor prognosis of children with PPH. |
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Authors:
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T Sato; T Akiba; H Suzuki; M Nakasato; S Sato; M Yoshikawa; S Yamaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 172 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-08-15 Completed Date: 1994-08-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yamagata University School of Medicine. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arterioles / pathology Child Child, Preschool Female Humans Hypertension, Pulmonary / pathology* Hypertrophy Infant Lung / pathology* Male Necrosis Pulmonary Artery / pathology |
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