Document Detail

Histopathologic findings of lung vessels in five children with primary pulmonary hypertension.
MedLine Citation:
PMID:  8036624     Owner:  NLM     Status:  MEDLINE    
A histopathologic study was carried out on pulmonary vessels of lung tissues from 5 children with primary pulmonary hypertension (PPH), in whom diagnosis was made on the basis of cardiac catheterization. Histological sections of lung were obtained in 4 patients by open lung biopsy and in one patient by closed needle necropsy soon after death. In all cases the vascular diseases were classified as grade 6 of the Heath-Edwards. Morphologic studies of small pulmonary arteries revealed medial hypertrophy (41.0%), intimal cellular proliferation (2.5%), intimal fibroelastic proliferation (36.9%) and medial destructive changes (19.6%) such as dilatation lesions, plexiform lesions, arteritis, or fibrinoid necrosis. Index of pulmonary vascular disease (IPVD) was 1.6 to 3.4 (mean 2.5). The advancement of these pulmonary changes sufficiently explains the extremely poor prognosis of children with PPH.
T Sato; T Akiba; H Suzuki; M Nakasato; S Sato; M Yoshikawa; S Yamaki
Related Documents :
9551734 - Bronchial temperature reflects transcapillary heat transport of isolated blood-perfused...
8816894 - Diffuse smooth muscle proliferation of the lungs with severe pulmonary hypertension.
24829084 - Anatomical study of suboccipital vertebral arteries and surrounding bony structures usi...
11390194 - Assessment of lung volumes in pulmonary emphysema using multidetector helical ct: compa...
6108164 - An analysis of the pulsatile hemodynamic responses of the pulmonary circulation to acut...
18037804 - Development of unusual collateral channel from the posterior meningeal artery after end...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  172     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-08-15     Completed Date:  1994-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Department of Pediatrics, Yamagata University School of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arterioles / pathology
Child, Preschool
Hypertension, Pulmonary / pathology*
Lung / pathology*
Pulmonary Artery / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of DNA polymerases alpha, delta, and epsilon of mouse cell line FM3A and its temperature-...
Next Document:  Changes of plasma lipid and lipoproteins by rehabilitation therapy for stroke.