Document Detail

Histopathologic findings of lung vessels in five children with primary pulmonary hypertension.
MedLine Citation:
PMID:  8036624     Owner:  NLM     Status:  MEDLINE    
A histopathologic study was carried out on pulmonary vessels of lung tissues from 5 children with primary pulmonary hypertension (PPH), in whom diagnosis was made on the basis of cardiac catheterization. Histological sections of lung were obtained in 4 patients by open lung biopsy and in one patient by closed needle necropsy soon after death. In all cases the vascular diseases were classified as grade 6 of the Heath-Edwards. Morphologic studies of small pulmonary arteries revealed medial hypertrophy (41.0%), intimal cellular proliferation (2.5%), intimal fibroelastic proliferation (36.9%) and medial destructive changes (19.6%) such as dilatation lesions, plexiform lesions, arteritis, or fibrinoid necrosis. Index of pulmonary vascular disease (IPVD) was 1.6 to 3.4 (mean 2.5). The advancement of these pulmonary changes sufficiently explains the extremely poor prognosis of children with PPH.
T Sato; T Akiba; H Suzuki; M Nakasato; S Sato; M Yoshikawa; S Yamaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  172     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-08-15     Completed Date:  1994-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Department of Pediatrics, Yamagata University School of Medicine.
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MeSH Terms
Arterioles / pathology
Child, Preschool
Hypertension, Pulmonary / pathology*
Lung / pathology*
Pulmonary Artery / pathology

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