Document Detail

Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study.
MedLine Citation:
PMID:  15854972     Owner:  NLM     Status:  MEDLINE    
Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.
Friedhelm Sayk; Inge Bos; Ute Schubert; Thilo Wedel; Hans-H Sievers
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  79     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2006-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1755-8     Citation Subset:  AIM; IM    
Institute of Pathology, University of Luebeck, Luebeck, Germany.
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MeSH Terms
Fatal Outcome
Heart Valve Prosthesis Implantation
Macrophages / pathology
Middle Aged
Pulmonary Valve Stenosis / pathology,  surgery*
Transplantation, Homologous

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