| Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study. | |
| | |
MedLine Citation:
|
PMID: 15854972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established. |
| | |
Authors:
|
Friedhelm Sayk; Inge Bos; Ute Schubert; Thilo Wedel; Hans-H Sievers |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 79 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-04-27 Completed Date: 2006-08-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1755-8 Citation Subset: AIM; IM |
Affiliation:
|
Institute of Pathology, University of Luebeck, Luebeck, Germany. friedhelm.sayk@innere1.uni-luebeck.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autopsy Fatal Outcome Heart Valve Prosthesis Implantation Humans Macrophages / pathology Male Middle Aged Pulmonary Valve Stenosis / pathology, surgery* Transplantation, Homologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Covered stent treatment of right pulmonary artery stenosis and Waterston shunt.
Next Document: Aortic atresia and type B interrupted aortic arch: diagnosis by physiologic cerebral monitoring.