Document Detail


Histopathologic features of alopecia areata incognito: a review of 46 cases.
MedLine Citation:
PMID:  22616601     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Alopecia areata (AA) incognito represents a variant of AA characterized by acute diffuse hair thinning. Dermoscopy shows yellow dots and short regrowing hairs. The differential diagnosis with telogen effluvium (TE) and androgenetic alopecia may be difficult. Methods: In order to establish histopathological criteria for the diagnosis of AA incognito, we evaluated retrospectively 92 specimens (46 horizontal and 46 vertical) of 46 patients diagnosed with AA incognito within 1 year. All specimens were assessed for 20 features, including hair counts and follicular ratios. The numbers were compared with 46 control specimens, consisting of 21 cases of TE and 25 cases of androgenetic alopecia. Results: The following main criteria are proposed: (a) preserved number of follicular units and decreased number of terminal follicles; (b) increased number of telogen structures (mean count of 37%) with presence of at least one telogen germinal unit or/and one small telogen follicle (c) decreased terminal:vellus ratio (mean ratio of 3.3 : 1) and (d) dilated infundibular openings. Conclusion: Two histopathologic clues for AA incognito include the presence of dilated infundibular openings and small basaloid aggregates of cells with round, irregular or polygonal shape, lack of hair shaft and no apoptosis in the outer root sheath, corresponding to small telogen follicles. Miteva M, Misciali C, Fanti PA, Tosti A. Histopathologic features of alopecia areata incognito: a review of 46 cases.
Authors:
Mariya Miteva; Cosimo Misciali; Piero A Fanti; Antonella Tosti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  39     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  596-602     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA Division of Dermatology, Department of Internal Medicine, Geriatrics and Nephrology, University of Bologna, Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections.
Next Document:  Proliferation and maturation of microvessels in arteriovenous malformations - expression patterns of...