| Histopathologic exploration of intra-hisian conduction disturbances. | |
| | |
MedLine Citation:
|
PMID: 11942594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: The length of the His bundle and the precise location of injury responsible for split His potentials have not been fully established in patients with intra-Hisian block. We conducted an autopsy study comparing histologic findings in intra-Hisian block versus control hearts. METHODS AND RESULTS: We studied hearts from 4 intra-Hisian block patients (age 66 to 93 years, mean 79.5) and hearts from 14 patients without AV conduction abnormalities (control). All intra-Hisian block patients underwent electrophysiologic evaluation; 3 patients demonstrated intra-Hisian block and 1 showed no His potential. Autopsies were performed when each patient died. After the heart was fixed in formaldehyde, the AV septal junctional area was removed en bloc and serially sectioned into 7-microm thick slices. For study purposes, we considered the three segments of the His bundle separately: the penetrating bundle, the nonbranching bundle, and the branching bundle. The actual length of each segment was calculated from the number of respective serial sections, and the lesion was reconstructed within the conduction axis. Intra-Hisian block hearts were heavier than control hearts (mean weight 389 vs 301 g; P < 0.05). The lesion was situated in the nonbranching bundle in 3 hearts and in the penetrating bundle in 1 heart. Mean compact node length was 3.8 mm in intra-Hisian block hearts and 3.3 mm in control hearts. The penetrating bundle was 2.1 and 2.1 mm, the nonbranching bundle was 3.5 and 1.9 mm, and the branching bundle was 4.5 and 4.6 mm in intra-Hisian block and control hearts, respectively. CONCLUSION: Most lesions were observed in the nonbranching bundle adjacent to the junction between the central fibrous body and ventricular septum. This segment was longer in intra-Hisian block hearts than in control hearts. |
| | |
Authors:
|
Taka-Aki Matsuyama; Shin Inoue; Youichi Kobayashi; Tsukasa Saito; Kaoru Tanno; Tetsuo Sakai; Toshihiko Otsuka; Akira Shiokawa; Takashi Katagiri; Hidekazu Ota |
Related Documents
:
|
2038074 - Vagally induced depression of impulse propagation as a cause of atrial tachycardia. 811214 - Experimental models of complete heart block. 12363174 - Heart block associated with spinocerebellar ataxia type 2. 10093854 - Diagnosis of acute myocardial infarction in patients with chronic left bundle-branch bl... 20506154 - Improving myocardial salvage in late presentation acute st-elevation myocardial infarct... 14739094 - Acute non-selective beta-adrenergic blockade reduces prolonged frequency-adjusted q-t i... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular electrophysiology Volume: 13 ISSN: 1045-3873 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-04-10 Completed Date: 2002-09-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
|
Second Department of Pathology, Showa University School of Medicine, Tokyo, Japan. zan42100@nifty.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Bundle of His / pathology* Bundle-Branch Block / etiology, pathology* Female Humans Male |
| Comments/Corrections | |
Comment In:
|
J Cardiovasc Electrophysiol. 2002 Mar;13(3):265-6
[PMID:
11942595
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome.
Next Document: Supervulnerable phase immediately after termination of atrial fibrillation.