| Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries. | |
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MedLine Citation:
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PMID: 2523707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reports on vascular pathology post-PTCA in both human and animal coronary vessels have revealed medial and intimal cracks and tears, thrombus formation, platelet accumulation, and loss of endothelial cells. The extent and type of damage can currently be assessed in vivo at the macro level by means of coronary artery angiography. However, this technique cannot define vessel wall characteristics at the cellular level. Our hypothesis is that vessel wall material may adhere to the balloon and thus provide a source for coronary artery cytological investigation in vivo. Ten balloon catheters were evaluated to discern any material which was dislodged from the coronary artery and which remained attached to the balloon catheter or guide wire. Our results indicate that angioplasty catheter balloons frequently have adherent collagen, endothelial cells, organized thrombus, and plaque with obvious cholesterol clefts, that can be retrieved and examined histologically. We conclude that material is often dislodged from the plaque during PTCA. In addition, plaque material removed by the balloon catheter offers an unusual opportunity to analyze the morphologic characteristics of cells from the human coronary artery in vivo. |
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Authors:
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D L Sprecher; E M Mikat; R Stack; K Sutherland; J Schneider; T Bashore; D B Hackel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Atherosclerosis Volume: 75 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-06-06 Completed Date: 1989-06-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
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University of Cincinnati Medical Center, Department of Pathology, OH 45267-0529. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina Pectoris / therapy Angioplasty, Balloon* Arteriosclerosis / pathology* Coronary Vessels / cytology, pathology* Female Humans Male Middle Aged Myocardial Infarction / therapy Specimen Handling / methods* |
| Grant Support | |
ID/Acronym/Agency:
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HLB 17670/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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