| Histopathologic evaluation of liver biopsy for cirrhosis. | |
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MedLine Citation:
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PMID: 22692285 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In current medical practice, the clinical diagnosis of cirrhosis is rendered when a patient has suggestive imaging findings or features of portal hypertension (pHTN). Liver biopsy may be considered to assess potential underlying cause(s). Cirrhosis, however, is not the only etiology of pHTN; in fact, schistosomiasis remains a significant factor worldwide. pHTN results from obstruction of hepatic blood flow; it is classified clinically based on either the anatomic location of obstruction or hepatic venous pressure gradient measurements. The clinical categories carry clinicopathologic significances. Histopathologically, pHTN is manifest with either cirrhotic or noncirrhotic features. Noncirrhotic pHTN results from a heterogeneous group of disease processes, all of which result in vascular remodeling with variable parenchymal nodularity and fibrosis. This review summarizes liver biopsy findings of cirrhosis and possible etiologies and provides a stepwise approach for the histologic differential diagnosis of a liver biopsy done for "cirrhosis." |
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Authors:
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Changqing Ma; Elizabeth M Brunt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in anatomic pathology Volume: 19 ISSN: 1533-4031 ISO Abbreviation: Adv Anat Pathol Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435676 Medline TA: Adv Anat Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 220-30 Citation Subset: IM |
Affiliation:
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Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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