Document Detail

Histopathologic effects of mitomycin-C on endoscopic transnasal dacryocystorhinostomy.
MedLine Citation:
PMID:  9101568     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: The antimetabolite mitomycin-C is now being used in endoscopic transnasal dacryocystorhinostomies to prevent the closure of osteotomies. PATIENTS AND METHODS: A 0.5-mg/ml solution of mitomycin-C was applied to the osteotomy site for 2 1/2 minutes intraoperatively. Specimens from four patients were collected during surgery and at 15 days, 1 months, 3 months, and 6 months after surgery. The specimens were examined under light and electron transmission microscopy and were compared with control specimens. RESULTS: Light microscopy showed attenuated epithelium with intracytoplasmic vacuoles. Subepithelial connective tissue was looser and hypocellular. Electron microscopy confirmed these findings and demonstrated swelling of mitochondria, dilatation of endoplasmic reticulum, and chromatin-dense granules in nuclei of fibroblasts. CONCLUSION: By causing a decrease in density and cellularity of mucosa, topical use of mitomycin-C may enhance the success of surgery; however, further studies are necessary to determine the ultimate potential of this agent for this procedure.
S H Ugurbas; G Zilelioglu; M F Sargon; Y Anadolu; M Akiner; T Aktürk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Ophthalmic surgery and lasers     Volume:  28     ISSN:  1082-3069     ISO Abbreviation:  Ophthalmic Surg Lasers     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-17     Completed Date:  1997-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9517132     Medline TA:  Ophthalmic Surg Lasers     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Department of Ophthalmology, Ankara University, Faculty of Medicine, Turkey.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage*
Endoscopy / methods*
Follow-Up Studies
Lacrimal Apparatus / drug effects,  pathology*
Lacrimal Duct Obstruction / drug therapy,  pathology*,  surgery
Mitomycin / administration & dosage*
Nasal Mucosa / drug effects,  pathology*
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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