Document Detail

Histopathologic correlation of hepatocellular carcinoma after transcatheter arterial chemoembolization with polyvinyl alcohol particle of various sizes.
MedLine Citation:
PMID:  21628086     Owner:  NLM     Status:  MEDLINE    
AIM: Transcatheter arterial chemoembolization (TACE) is one of major treatment for unresectable hepatocellular carcinomas (HCC) and has been used as a neoadjuvant treatment before surgery. This study was to describe the histopathologic features of HCC after TACE with variously sized polyvinyl alcohol (PVA) particles.
MATERIALS AND METHODS: Seventeen patients undergoing TACE with PVA followed by surgery for HCC were analyzed. The PVA particles used in TACE were categorized into two groups in respects of particle sizes: the group I, 47-90 μm (n=8) and the group II, >90-250 μm (n=9). The histopathologic features of the resected HCC were characterized with the emphasis on the number of thrombosed vessels and minimal diameter of arterioles/capillaries containing polyvinyl alcohol particles. The clinical results after TACE were also addressed.
RESULTS: Histopathologic examinations showed that the median minimal diameters of arterioles containing PVA particles were 0.035 mm in group I and 0.06 mm in group II (p=0.0078). We observed the PVA particle in the sinusoidal spaces of non-tumourous liver in only one patient. However, no sinusoidal infarction was demonstrated in either group. Mean tumour necrosis rate was 67% vs. 61% for the group I and II, respectively.
CONCLUSIONS: The smaller PVA particles can reach and occlude more distal arteriolar capillaries, but rarely leak into non-tumourous hepatic sinusoidal spaces. Slightly better tumour necrosis rate after TACE can be achieved.
Ming-Yuan Lee; Vincent P Chuang; Chao-Jung Wei; Tsung-Yen Cheng; Ming-Tsu Cherng
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article     Date:  2011-05-31
Journal Detail:
Title:  European journal of radiology     Volume:  81     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-10     Completed Date:  2013-01-14     Revised Date:  2014-01-30    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1976-9     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Carcinoma, Hepatocellular / pathology*,  therapy*
Catheterization, Peripheral / methods*
Chemoembolization, Therapeutic / instrumentation*
Liver Neoplasms / pathology*,  therapy*
Middle Aged
Particle Size
Polyvinyl Alcohol / chemistry*,  therapeutic use*
Statistics as Topic
Treatment Outcome
Reg. No./Substance:
9002-89-5/Polyvinyl Alcohol

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